Luxembourg

Luxembourg needs almost nothing from a travel medicine standpoint — routine vaccines, an MMR check against the ongoing European measles picture, and confirmation that your insurance covers you — which frees the consultation for the thing most Americans don't know: this is a serious hiking destination. The Müllerthal Trail's 70 miles of sandstone gorges earn the "Little Switzerland" name, and they generate the two conversations worth having. First, ticks: Lyme disease is present in Luxembourg's forests and TBE circulates at low levels, so do a full tick check after any forest day, and for travelers planning extensive spring-through-autumn hiking the TBE vaccine is a reasonable discussion. Second, footwear: wet sandstone is genuinely slippery, and ankle-support boots matter more here than almost anywhere in Western Europe.

Beyond the trails: keep bags in sight on the Brussels–Luxembourg train — the one recurring crime pattern — winter tires are standard November through March if you're driving the Ardennes, and CHL in Luxembourg City provides European-standard care, with Aachen and Brussels an hour away for anything complex.