Central African Republic

Health Overview
Key Health Risks
Health Risk Callout
Other Health Risks
Regional Information
Vaccine and Malaria Prevention
- Risk Level: High
- Areas: All areas year-round including Bangui
- Recommended Drug: Atovaquone-proguanil; doxycycline; mefloquine; tafenoquine
- Drug Resistance: Yes
P. falciparum dominant; chloroquine-resistant. One of highest burden rates globally. Bangui's equatorial climate: exceptionally high year-round. Collapsed healthcare means malaria diagnosed here cannot be reliably treated — IV artesunate may not be available. Prophylaxis compliance is arguably a survival decision.
Physician Note
STRONGLY RECOMMEND NOT TRAVELING. CAR: 'Embassy Bangui cannot provide consular services. If something goes wrong, your contact is Yaoundé, Cameroon.' Then: malaria prophylaxis in one of world's highest-transmission environments is a survival decision.
Rabies PrEP uniquely critical — PEP does not exist. Global Polio THN names CAR. Be sure to consult your Dr. prior to travel to discuss.
Pre-Departure Checklist
8+ Weeks
- DO NOT TRAVEL — Central African Republic is Level 4. Only authorized NGO or UN deployment with a security framework should proceed
- CDC recommends YF — REQUIRED for ALL arriving travelers ≥9 months regardless of origin
- Routine vaccines including MMR (CAR is named on the Measles THN)
- Hepatitis A
- Hepatitis B
- Typhoid
- Meningococcal ACWY
- Rabies pre-exposure — STRONGLY recommended, since post-exposure prophylaxis is essentially unavailable
- Polio IPV booster — CRITICAL: CAR is on the Polio THN (March 2026).
2–4 Weeks
- Register with STEP
- Confirm medevac insurance and a security organization — both are mandatory
- Carry a complete medication supply from home
- Establish a departure plan that does not depend on US government assistance.
Day Of
- State Dept 24/7: +1-202-501-4444
- US citizen emergencies: Embassy Yaoundé +(237) 22220-1500 ext. 4341/4023; after hours ext. 4531
- Emergency services are unreliable and unlikely to respond outside Bangui — arrange private transport to a facility rather than waiting for an ambulance
- Do not travel outside Bangui without a security escort.
Trip Type Guidance
Mission only: MSF; ICRC; UN agencies; faith-based with full security infrastructure. Individual/small-team travel not viable. HEAT training; medevac contract; K&R insurance mandatory.

