Afghanistan

Health Overview
Key Health Risks
Health Risk Callout
Other Health Risks
Regional Information
Vaccine and Malaria Prevention
- Risk Level: Moderate
- Areas: Rural areas below 6,600 feet; eastern provinces highest; Kabul 5,900 feet lower but non-zero; seasonal July-October
- Recommended Drug: Atovaquone-proguanil; chloroquine (P. vivax areas); doxycycline; mefloquine; tafenoquine; primaquine terminal prophylaxis
- Drug Resistance: Yes
Afghanistan malaria clinically distinct: P. vivax dominates (~70-80%). Hypnozoite problem requires primaquine terminal prophylaxis.
Physician Note
I do not recommend travel here currently. Afghanistan is Level 4 with no US embassy, no consular services, and — since February 2026 — an active interstate war with Pakistan layered over Taliban detention risk and IS-K bombings. These notes exist for authorized humanitarian personnel only, and the medical planning problem is unusual: Kabul's facilities have been damaged in the war itself, and the standard evacuation route to Islamabad now crosses into the opposing party of an active conflict while the FAA NOTAM restricts Afghan airspace — several providers will not fly at all. Get the evacuation commitment in writing, with the destination named, before entry.
Clinically, Afghanistan is distinctive: malaria is P. vivax-dominant (roughly 70–80%), which means the hypnozoite liver stage — discuss primaquine terminal prophylaxis and test G6PD first. Cutaneous leishmaniasis is endemic in Kabul itself; permethrin and DEET are not seasonal suggestions here. Afghanistan remains one of the last countries with wild poliovirus transmission — the booster is mandatory, not optional. And rabies post-exposure prophylaxis is largely unavailable in-country, which converts pre-exposure vaccination from a consideration into a serious recommendation for any extended deployment.
Pre-Departure Checklist
8+ Weeks
- DO NOT TRAVEL HERE — Afghanistan is Level 4 with no US Embassy, no consular services, and an active interstate war with Pakistan since February 2026. Only authorized NGO or humanitarian deployment with a full security framework should proceed
- Polio booster — REQUIRED, not optional; Afghanistan is one of the last countries with active poliovirus transmission and is named on the Global Polio Level 2 THN
- Routine vaccines including MMR (active CDC measles notice for Afghanistan)
- Hepatitis A
- Hepatitis B
- Typhoid
- Rabies pre-exposure — strongly recommended; post-exposure prophylaxis is largely unavailable
- Meningococcal for extended stays
- Malaria prophylaxis for rural areas below 6,600 feet — note Afghanistan is P. vivax dominant (~70-80%), so discuss primaquine terminal prophylaxis for the hypnozoite stage and test G6PD before prescribing.
2–4 Weeks
- Confirm medical evacuation cover AND a security organization in writing — both mandatory; several providers will not fly Afghan airspace and the FAA NOTAM/SFAR applies
- Confirm evacuation routing: Islamabad crosses into the opposing party of the active conflict and borders have been repeatedly closed; Dubai is the alternative
- Establish a proof-of-life protocol; Taliban detention of foreigners and dual nationals is documented
- Ensure will and power of attorney are current
- Carry a complete medication supply from home plus reserve — do not rely on local resupply
- Water purification capability
- DEET and permethrin-treated clothing (malaria and sandfly-borne cutaneous leishmaniasis, which is endemic in Kabul).
Day Of
- State Dept 24/7: +1-202-501-4444 — there is no embassy to call; AfghanistanACS@state.gov is the only channel
- EMERGENCY Surgical Centre for War Victims, Kabul — verify it is operating before relying on it
- Local emergency 119 (may not be answered); there is no reliable ambulance service
- Never touch unknown objects — landmine and UXO contamination is extensive
- Bottled or purified water only; thoroughly cooked food only; no unpasteurized dairy (brucellosis)
- Daily check-ins with your organization.
Trip Type Guidance
No trip types appropriate. Embassy closed. Only authorized NGO with security frameworks.

